Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 3. The effect of thymectomy

J Neurol Sci. 1985 Jul;69(3):335-43. doi: 10.1016/0022-510x(85)90144-3.


The clinical condition and the serum levels of antibodies to acetylcholine receptor protein were followed in 30 patients with myasthenia gravis before and in a period varying from 2 to 4 (mean 3) yr after thymectomy. Twenty-five patients improved in the 2 yr following thymectomy. A highly significant correlation was found between the change in clinical condition and the change in antibody levels. Only 3 patients improved without a fall of antibody level. Prethymectomy antibody levels were positively correlated with the severity of the clinical condition and with the degree of thymus hypertrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / analysis*
  • Child
  • Female
  • Humans
  • Hypertrophy
  • Male
  • Myasthenia Gravis / immunology*
  • Myasthenia Gravis / pathology
  • Myasthenia Gravis / therapy
  • Receptors, Cholinergic / immunology*
  • Thymectomy*
  • Thymus Gland / pathology*


  • Autoantibodies
  • Receptors, Cholinergic