Kinetics of hydrochlorothiazide absorption in humans

J Pharm Sci. 1985 Jul;74(7):765-7. doi: 10.1002/jps.2600740714.


The kinetics of absorption of hydrochlorothiazide was studied in four adult male volunteers. Plasma levels were monitored for 48 h after a 100-mg dose. Food, electrolyte, and water intake were regulated as far as possible. The plasma level data were fitted to a two-compartment open model with either first-order or zero-order absorption, using the pharmacokinetic computer program AUTOAN. A better fit of the data, both graphically and statistically, was obtained with zero-order absorption kinetics. Additional confirmation of absorption kinetics was obtained by treating the plasma level results by the Loo-Riegelman method. Cartesian graphs of the amount absorbed verus time afforded linear plots, which indicate a zero-order process.

MeSH terms

  • Administration, Oral
  • Adult
  • Humans
  • Hydrochlorothiazide / blood
  • Hydrochlorothiazide / metabolism*
  • Intestinal Absorption
  • Kinetics
  • Male
  • Middle Aged
  • Models, Biological


  • Hydrochlorothiazide