ER-to-lysosome-associated degradation

Maurizio Molinari

doi:10.1016/j.cub.2025.03.068

ER-to-lysosome-associated degradation

Curr Biol. 2025 May 5;35(9):R320-R322. doi: 10.1016/j.cub.2025.03.068.

Author

Maurizio Molinari¹

Affiliation

¹ Università della Svizzera italiana, Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland; School of Life Sciences, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address: maurizio.molinari@irb.usi.ch.

PMID: 40328214
DOI: 10.1016/j.cub.2025.03.068

Abstract

Maurizio Molinari introduces ER-to-lysosome-associated degradation - the autophagic and non-autophagic pathways that deliver ERAD-resistant misfolded proteins to the lysosome for degradation to maintain cellular proteostasis.

MeSH terms

Animals
Autophagy* / physiology
Endoplasmic Reticulum* / metabolism
Endoplasmic Reticulum-Associated Degradation* / physiology
Humans
Lysosomes* / metabolism
Proteolysis
Proteostasis