Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism

Carmine Siniscalchi; Tiziana Meschi; Pierpaolo Di Micco; Egidio Imbalzano; Luis Hernández-Blasco; Isabelle Mahé; José Luis Fernández-Reyes; Alberto García-Ortega; Peter Verhamme; Joaquín Alfonso-Megido; Manuel Monreal; RIETE Investigators

doi:10.1001/jamanetworkopen.2025.9467

Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism

JAMA Netw Open. 2025 May 1;8(5):e259467. doi: 10.1001/jamanetworkopen.2025.9467.

Affiliations

¹ Department of Internal Medicine, Parma University Hospital, Parma, Italy.
² AFO Medicina PO Santa Maria delle Grazie, Pozzuoli Naples Hospital 2 Nord, Naples, Italy.
³ Division of Internal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
⁴ Pneumology Department of Clinical Medicine, Miguel Hernández University, ISABIAL, Dr. Balmis University General Hospital, Alicante, Spain.
⁵ Department of Internal Medicine, Hôpital Louis Mourier, Assistance Publique des Hôpitaux de Paris (AP-HP), Colombes, France.
⁶ Université Paris Cité, France. INSERM UMR-S-1140, Paris, France.
⁷ Department of Internal Medicine, Complejo Hospitalario de Jaén, Jaén, Spain.
⁸ Department of Pneumonology, Hospital Universitario Doctor Peset, Valencia, Spain.
⁹ Vascular Medicine and Haemostasis, University of Leuven, Leuven, Belgium.
¹⁰ Hospital Valle del Nalón, Department of Internal Medicine, Langreo, Asturias, Spain.
¹¹ Chair for the Study of Thromboembolic Disease, Faculty of Health Sciences, UCAM - Universidad Católica San Antonio de Murcia, Murcia, Spain.
¹² CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.

No abstract available

Plain language summary

This case-control study evaluates low-density lipoprotein cholesterol levels and bleeding risk during anticoagulation in patients with acute venous thromboembolism.