When Shared Decision-Making Breaks Down: Solving Moral Dilemmas in Antipsychotic Deprescribing

Harv Rev Psychiatry. 2025 May-Jun;33(3):170-177. doi: 10.1097/HRP.0000000000000430.

Abstract

Many individuals diagnosed with psychosis make multiple attempts to discontinue antipsychotic medications. In this clinical challenge, we examine three snapshots in which shared decision-making (SDM) breaks down due to ongoing disagreement between the service user and the health care provider. We offer three perspectives on how to think about such disagreement: philosophical, psychological, and psychiatric perspectives. Finally, we propose shared deliberation as a potential model for when SDM fails, emphasizing an iterative process of mutual value sharing that avoids binary yes/no responses.

Keywords: autonomy; justice; psychosis; shared decision-making; shared deliberation.

MeSH terms

  • Antipsychotic Agents* / therapeutic use
  • Decision Making, Shared*
  • Deprescriptions*
  • Ethical Dilemmas
  • Humans
  • Morals*
  • Psychotic Disorders* / drug therapy

Substances

  • Antipsychotic Agents