Personalized Dietary Approaches to Optimizing Intestinal Microbial Health and Homeostasis

Gastroenterol Clin North Am. 2025 Jun;54(2):317-331. doi: 10.1016/j.gtc.2024.12.008. Epub 2025 Jan 24.

Abstract

Diet has a profound impact in human health, which is partly driven by changes in the intestinal microbiota. Several associations between dietary intake and the intestinal microbiota composition and function have been described. Namely, the Mediterranean diet is associated with beneficial bacteria, while the intake of ultraprocessed foods is linked to dysbiosis. It is, therefore, very tempting to tailor dietary approaches to the individual needs of the microbiota; however, high-quality prospective data are lacking. Provisionally, a diet rich in fruits and vegetables and low in ultraprocessed foods is recommended to improve the intestinal microbiota composition and function.

Keywords: Diet; Microbiome; Microbiota; Nutrition; Personalized.

Publication types

  • Review

MeSH terms

  • Diet*
  • Diet, Mediterranean
  • Dysbiosis
  • Fruit
  • Gastrointestinal Microbiome* / physiology
  • Homeostasis*
  • Humans
  • Precision Medicine*