Navigating Composite Endpoints: Methods and Recommendations for Trial Design and Interpretation

J Card Fail. 2025 May 9:S1071-9164(25)00202-7. doi: 10.1016/j.cardfail.2025.04.008. Online ahead of print.

Authors

Jessica R Overbey¹, Robert J Mentz², Cora Allen-Savietta³

Affiliations

¹ Berry Consultants, LLC, Austin, Texas; Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: jessica@berryconsultants.net.
² Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina.
³ Berry Consultants, LLC, Austin, Texas.

PMID: 40349950
DOI: 10.1016/j.cardfail.2025.04.008

No abstract available

Keywords: Composite endpoints; recurrent events; trial design.

Publication types

Review