Responsiveness and receptive field size of carp horizontal cells are reduced by prolonged darkness and dopamine

Science. 1985 Sep 13;229(4718):1107-9. doi: 10.1126/science.4035351.


In the fish retina the interplexiform cells contain dopamine and provide a centrifugal pathway from the inner plexiform layer to horizontal cells of the outer plexiform layer. Dopamine application reduced the responsiveness and receptive field size of cone horizontal cells, as did a prolonged period of complete darkness. Other results suggest that the interplexiform cells may release dopamine after a prolonged period in the dark. The interplexiform-horizontal cell system may modify the strength of the antagonistic surrounds of retinal neurons as a function of time in the dark.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Darkness*
  • Dopamine / pharmacology*
  • Electrophysiology
  • Evoked Potentials
  • Fishes
  • Light
  • Membrane Potentials
  • Retina / cytology*
  • Retina / drug effects
  • Time Factors


  • Dopamine