99mTc-PSMA Scintigraphy in Splenic Hemangioma

Ahmad Ghasemifard; Amin Saber Tanha; Faeze Rabani; Amir Behforouz; Emran Askari

doi:10.1097/RLU.0000000000005969

99mTc-PSMA Scintigraphy in Splenic Hemangioma

Clin Nucl Med. 2025 May 12. doi: 10.1097/RLU.0000000000005969. Online ahead of print.

Authors

Ahmad Ghasemifard¹, Amin Saber Tanha², Faeze Rabani², Amir Behforouz¹, Emran Askari²

Affiliations

¹ Department of Radiology.
² Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 40358416
DOI: 10.1097/RLU.0000000000005969

Abstract

A 67-year-old man was referred for initial staging of prostate adenocarcinoma (Gleason score 4+3, 7/12 cores positive). A 99mTc-PSMA scintigraphy revealed localized uptake in the right prostate lobe (miTNM: T2mN0M0, and PRIMARY score: 5) and increased uptake in a hypo-dense splenic lesion (PSMA-RADS-3C), which was subsequently confirmed as a hemangioma on further evaluations. This case underscores the potential for false-positive 99mTc-PSMA uptake in splenic hemangiomas, highlighting the importance of considering this possibility in clinical practice.

Keywords: SPECT/CT; false-positive; prostate cancer; splenic hemangioma.