Higher adherence to the EAT-Lancet reference diet is inversely associated with mortality in a UK population of cancer survivors

BMC Med. 2025 May 13;23(1):286. doi: 10.1186/s12916-025-04106-x.

Abstract

Background: Significant advancements in treatment and care, as well as early detection, have contributed to an increase in cancer survival rates. Recently, the EAT-Lancet Commission on Food, Planet, Health proposed the "planetary health diet" but to date, no study has investigated the potential associations between adherence to the EAT-Lancet reference diet and mortality in cancer survivors. To determine whether higher adherence to the EAT-Lancet reference diet is associated with lower risk for all-cause, cancer, and cardiovascular mortality in cancer survivors.

Methods: Data from the prospective UK Biobank study were used. Information from UK Biobank's Touchscreen questionnaire was used to develop a score reflecting adherence to the EAT-Lancet reference diet. Cox proportional hazards regression was used to assess the association of the EAT-Lancet reference diet score with all-cause, cancer, and cardiovascular mortality in cancer survivors.

Results: Within 25,348 cancer survivors, better adherence to the EAT-Lancet reference diet was inversely related to all-cause mortality (hazard ratio (HR): 0.97, 95% confidence interval (CI): 0.95-0.99), 1 unit increase) and cancer mortality (HR: 0.98, 95% CI: 0.96-1.00), while mostly null associations were observed for major cardiovascular mortality (HR: 0.99, 95% CI: 0.95-1.03).

Conclusions: Our findings suggest the adoption of the EAT-Lancet reference diet is associated with lower all-cause and cancer-specific mortality among cancer survivors.

Keywords: Cancer; Diet; EAT-Lancet; Mortality; Survivors; Sustainable.

MeSH terms

  • Adult
  • Aged
  • Cancer Survivors* / statistics & numerical data
  • Cardiovascular Diseases / mortality
  • Diet*
  • Diet, Healthy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasms* / mortality
  • Prospective Studies
  • United Kingdom / epidemiology