Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors

Abstract

This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). These compounds target the ifenprodil binding site of the NMDA receptor and exhibit enhanced metabolic stability compared to traditional phenolic-based molecules.