Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth

Am J Pathol. 1985 Sep;120(3):327-32.

Abstract

Two heparin-binding proteolytic fragments of fibronectin--an amino-terminal 29-kd segment and a carboxyl-terminal 40-kd segment-are apparently specific, potent inhibitors of the growth of cultured bovine aortic endothelial cells and inhibit growth in a reversible, dose-dependent manner. In contrast, native fibronectin at higher dosages neither inhibits nor interferes with the effects of the 29-kd fragment. The data, therefore, suggest that fibronectin fragments may participate in the regulation of vascular growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta / cytology
  • Aorta / drug effects*
  • Cattle
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Chemical Phenomena
  • Chemistry
  • Endothelium / drug effects
  • Fibronectins / metabolism
  • Fibronectins / pharmacology*
  • Heparin / metabolism*
  • Humans
  • Peptide Fragments / isolation & purification
  • Peptide Fragments / pharmacology*
  • Thrombin

Substances

  • Fibronectins
  • Peptide Fragments
  • Heparin
  • Thrombin