Zebrafish as a model for olfactory research: A systematic review from molecular mechanism to technology application

Abstract

Zebrafish with unique biological traits can serve as an ideal model for studying olfactory mechanisms. This review analyzes their olfactory system, focusing on the regulation of receptor gene expression, mechanisms of odor recognition, and research methodologies including behavioral assays, molecular docking, and biotechnological approaches. Current limitations include predominantly qualitative data, insufficient cross-species comparisons, and unclear mechanisms of environmental modulation. Nevertheless, zebrafish models show significant potential in deciphering human olfaction and applications in neuroscience, biotechnology, healthcare, food safety, and environmental monitoring. Future research should establish cross-species olfactory databases, standardize behavioral assessments, and resolve technical bottlenecks to advance applications in precision medicine, food quality control, and pollutant detection.

Keywords: Applications; Interactions; Odor molecules; Olfactory receptors; Zebrafish.