The mammary gland is one of the most important glands in human body, and the abnormal changes of its tissue mechanics are often closely related to the occurrence and development of mammary gland diseases. With the development of two new interdisciplines, biomechanics and mechanobiology, their theoretical research results have been gradually transformed into clinical applications, resulting in two new clinical disciplines, mechanodiagnostics and mechanotherapy. However, many clinicians still lack a systematic and in-depth understanding of the biomechanical characteristics and mechanobiology of breast tissue, and their potential value in the clinical diagnosis and treatment of breast diseases. In view of this, we elaborated the evolution law of the biomechanical characteristics and mechanobiological mechanism of breast diseases from four aspects: breast biomechanics, breast mechanobiology, breast mechanodiagnostics, and breast mechanotherapy, analyzed their role in the occurrence and development of breast diseases, and discussed the mechanical principles involved in the traditional diagnosis and treatment of breast diseases, to provide new ideas and schemes for the diagnosis and treatment of breast diseases.
乳腺是人体重要的腺体之一，其组织力学特征的异常变化往往与乳腺疾病的发生发展密切相关。随着生物力学和力生物学这两个新兴交叉学科的发展，其理论研究成果逐渐被转化应用于临床，产生了力诊断学和力治疗学两个着眼于临床需求的应用学科新方向。然而，很多临床医师对乳腺组织的生物力学特征和力生物学机制尚缺乏系统深入的了解，对乳腺生物力学和力生物学在乳腺疾病临床诊疗中的潜在价值尚未能充分认识。鉴于此，笔者从乳腺生物力学、乳腺力生物学、乳腺力诊断学和乳腺力治疗学4个方面阐述了乳腺疾病的生物力学特征演变规律和力生物学机制，分析了其在乳腺疾病发生发展中所起的作用，探讨了乳腺疾病传统诊疗方式中涉及的力学原理，以及利用靶向生物力学特征和力生物学标志物进行乳腺疾病诊疗的新方法，旨在为乳腺疾病的诊疗提供新的思路和方案。.