Usefulness of heparin in initial management of patients with recent transient ischemic attacks

Arch Neurol. 1985 Oct;42(10):960-2. doi: 10.1001/archneur.1985.04060090042011.


We evaluated the efficacy of short-term intravenous heparin therapy in 74 patients with recent transient ischemic attacks (TIAs). The patients were treated after hospitalization until operation or long-term medical treatment was instituted. Heparin was given in a continuous infusion to maintain an activated partial thromboplastin time of 1 1/2 to 2 1/2 times control values. During the treatment period, 12 patients (16.2%) had recurrent TIAs and five (6.8%) had cerebral infarction. Bleeding complications occurred in nine patients (12.2%). In this limited series, heparin did not prevent recurrent TIAs or cerebral infarction among high-risk patients with recent TIAs.

MeSH terms

  • Adult
  • Aged
  • Cerebral Infarction / etiology
  • Cerebral Infarction / prevention & control*
  • Female
  • Heparin / adverse effects
  • Heparin / therapeutic use*
  • Humans
  • Ischemic Attack, Transient / complications
  • Ischemic Attack, Transient / drug therapy*
  • Male
  • Middle Aged


  • Heparin