The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer: relationships with metabolic clearance rates of oestradiol

Int J Cancer. 1985 Apr 15;35(4):457-60. doi: 10.1002/ijc.2910350407.

Abstract

The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast cancer (1.8 +/- 0.4%, mean +/- SD) and normal women (1.6 +/- 0.3%). Approximately 40% of oestradiol in plasma was bound to albumin with 60% bound to sex hormone binding globulin (SHBG), but values were similar for women with or without breast cancer. Concentrations of total unconjugated oestradiol and free oestradiol (2.4 +/- 0.5 ng/100 ml and 44 +/- 12 pg/100 ml respectively, mean +/- SD, n = 9) were significantly higher in plasma from postmenopausal women with breast cancer compared with levels in plasma from normal postmenopausal women (1.8 +/- 0.5 ng/100 ml and 27 +/- 10 pg/100 ml, n = 8). A significant correlation was found between the free oestradiol fraction and MCR-E2 (r = 0.53, p less than 0.05). Correlations were also found between the fractions of oestradiol bound to albumin and MCR-E2 (r = 0.45). From correlations between the binding capacity of SHBG and MCR-E2 it appears that, for a given level of SHBG, MCR-E2 may be higher in women with breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Weight
  • Breast Neoplasms / blood
  • Breast Neoplasms / metabolism*
  • Chemical Precipitation
  • Estradiol / blood*
  • Female
  • Humans
  • Menopause*
  • Metabolic Clearance Rate
  • Middle Aged
  • Protein Binding
  • Radioimmunoassay
  • Serum Albumin / metabolism
  • Sex Hormone-Binding Globulin / metabolism

Substances

  • Serum Albumin
  • Sex Hormone-Binding Globulin
  • Estradiol