Physical activity and albuminuria in individuals recently diagnosed with type 2 diabetes

Abstract

Aims: We aimed to investigate the association between objectively measured physical activity and the presence and development of albuminuria in individuals recently diagnosed with type 2 diabetes at baseline.

Methods: This study was based on data from The Danish Centre for Strategic Research in Type 2 diabetes cohort (N = 832). We assessed moderate to vigorous physical activity (MVPA) and sedentary time by 24-hour dual-monitor accelerometry at baseline and 4-years follow-up and investigated the association with albuminuria, defined as urine albumin/creatinine-ratio (UACR) ≥30 mg/g, measured from a urine sample. The odds ratio (OR) for the presence and development of albuminuria were investigated using multiple logistic regressions.

Results: We found an inverse association between baseline MVPA and both presence (OR: 0.82; 95 % CI: 0.69-0.98) and incidence of albuminuria (OR: 0.74; 95 % CI: 0.59-0.94), independent of known confounding factors. However, sedentary time was not significantly associated with increased development of albuminuria. Moreover, neither decrease in MVPA (OR: 0.79; 95 % CI: 0.42-1.49) nor increase in sedentary time (OR: 1.03; 95 % CI: 0.98-1.09) were significantly associated with development of albuminuria from baseline to 4-years follow-up.

Conclusions: Our findings demonstrate an inverse association between baseline MVPA and development of albuminuria in individuals recently diagnosed with type 2 diabetes. An increase in MVPA from baseline to follow-up inferred 21 % lower incidence of albuminuria after 4-years follow-up, albeit insignificant, likely due to the relatively small sample size at follow-up and the lack of larger changes in physical activity.

Clinical trial registration number: NCT02015130.

Keywords: Accelerometer; Albuminuria; Physical activity; Sedentary time; Type 2 diabetes mellitus.