Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

Biochem Pharmacol. 1985 Jul 15;34(14):2583-6. doi: 10.1016/0006-2952(85)90551-9.
No abstract available

MeSH terms

  • Buthionine Sulfoximine
  • Cell Line
  • Cell Survival / drug effects
  • Cisplatin / pharmacology*
  • Doxorubicin / metabolism
  • Doxorubicin / pharmacology*
  • Drug Resistance
  • Drug Synergism
  • Female
  • Glutathione / metabolism*
  • Humans
  • Melphalan / metabolism
  • Melphalan / pharmacology*
  • Methionine Sulfoximine / analogs & derivatives*
  • Methionine Sulfoximine / pharmacology
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology

Substances

  • Methionine Sulfoximine
  • Buthionine Sulfoximine
  • Doxorubicin
  • Glutathione
  • Cisplatin
  • Melphalan