PET/CT in the Imaging of CNS Tumors

Semin Nucl Med. 2025 Jul;55(4):475-486. doi: 10.1053/j.semnuclmed.2025.04.002. Epub 2025 May 21.

Abstract

Central nervous system (CNS) tumors are quite rare but cause significant morbidity and mortality. Positron Emission Tomography (PET) is a widely utilized imaging modality within the field of nuclear medicine. CNS tumor diagnostics are an essential tool in the diagnosis and treatment of patients with glioma, offering valuable insights into tumor characteristics, treatment response and outcomes. A variety of different tracers are used in PET imaging of brain tumors including 18F-labeled fluorodeoxyglucose ([18F]FDG), markers showing amino acid metabolism, angiogenesis or inflammatory processes. In this article we describe possibility of use different tracers in different clinical scenario of CNS tumors.

Publication types

  • Review

MeSH terms

  • Central Nervous System Neoplasms* / diagnostic imaging
  • Humans
  • Positron Emission Tomography Computed Tomography* / methods