Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

Nature. 1985 Aug 29-Sep 4;316(6031):774-8. doi: 10.1038/316774a0.


The enzymatic machinery that carries out RNA synthesis provides the cell with the means to adjust the patterns of transcription in response to environmental and developmental signals. In eukaryotes, this regulation is mediated in part by promoter-specific transcription factors, which are DNA-binding proteins with the ability to discriminate between distinctive DNA sequence elements found in the promoter regions of different genes. The presence of these factors bound to DNA enables other components of the transcriptional machinery, including the RNA polymerase, to initiate transcription with selectivity and accuracy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Binding Sites
  • DNA-Binding Proteins / metabolism*
  • Enhancer Elements, Genetic
  • Promoter Regions, Genetic
  • RNA Polymerase II / metabolism
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • DNA-Binding Proteins
  • RNA, Messenger
  • Transcription Factors
  • RNA Polymerase II