A Case of Guillain-Barré Syndrome Possibly Associated With COVID-19 Infection

Cureus. 2025 Apr 24;17(4):e82954. doi: 10.7759/cureus.82954. eCollection 2025 Apr.

Abstract

Guillain-Barré syndrome (GBS) is a neurological disorder characterized by progressive and symmetric muscle weakness accompanied by the absence or depression of deep tendon reflexes. It is typically associated with a preceding viral infection, such as the Epstein-Barr virus, cytomegalovirus, hepatitis E virus, and Zika virus, or bacterial pathogens like Campylobacter jejuni and Mycoplasma pneumoniae. Recently, rare cases of GBS have been reported following infection with COVID-19, suggesting a potential association between SARS-CoV-2 and GBS. In this report, we present a clinically and diagnostically confirmed case of GBS following COVID-19 reinfection, which supports emerging data on the neurological complications associated with subsequent episodes of infection by the novel coronavirus.

Keywords: acute inflammatory demyelinating polyneuropathy (aidp); covid-19; electrodiagnostic study; guillain-barre syndrome (gbs); intravenous immunoglobulin (ivig).

Publication types

  • Case Reports