Dopamine changes the shape of action potentials in hippocampal pyramidal cells

Brain Res. 1985 Sep 9;342(2):386-90. doi: 10.1016/0006-8993(85)91143-6.


Dopamine was found to have two electrophysiological effects on CA1 pyramidal cells in rat hippocampal slices. It increased the slow afterhyperpolarisation caused by a slow Ca2+-activated K+ conductance and it had an effect on action potentials that is postulated to be due to an increase in a fast Ca2+-activated K+ conductance. A given CA1 cell showed either one or both of the two responses to dopamine, or no response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Dopamine / pharmacology*
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • In Vitro Techniques
  • Rats


  • Dopamine