Pulmonary gas exchange and exercise performance in pulmonary hypertension

Chest. 1985 Oct;88(4 Suppl):255S-257S. doi: 10.1378/chest.88.4_supplement.255s.


Patients with pulmonary hypertension have disordered pulmonary gas exchange and impaired exercise tolerance. The hypoxemia is due to mild ventilation-perfusion (VA/Q) inequality exaggerated by the presence of a low mixed venous PO2 (PvO2) and is accentuated during exercise due to a further fall in PvO2. This in turn may be worsened by vasodilators which increase the degree of VA/Q inequality. Decreased exercise tolerance is due predominantly to cardiac limitation, and thus an improvement in cardiac function subsequent to successful vasodilation can be assessed by improved exercise performance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Humans
  • Hypertension, Pulmonary / physiopathology*
  • Physical Exertion*
  • Pulmonary Gas Exchange*