Engineering PEG-alginate microcarriers for precision drug Delivery: Optimized design and controlled release

Abstract

In recent years, polymeric microcarriers have emerged as a targeted approach for controlled drug release. With advantages such as increased drug delivery efficiency, controlled release mechanisms, exceptional stability, and targeted release capabilities, microcarriers have become a focal point of research in drug delivery strategies. In this study, polyethylene glycol (PEG) was first functionalized with sialic acid (SA), and the resulting structure was evaluated using FTIR analysis. The dropwise extrusion method was utilized to form the microcarriers. We employed the central composite design (CCD) method to optimize the fabrication of polymeric microcarriers. Finally optimized microcarriers were prepared with an average particle size of 880 ± 2 μm. In the optimal microcarrier, the amounts of loaded drug and its efficiency were 90 % and 91 %, respectively. The results indicated the release of curcumin in the prepared system compared to free curcumin was controlled and long-lasting. The utilization of polymeric microcarriers as a targeted approach for controlled drug release holds great promise in revolutionizing the field of drug delivery. This research not only enhances our understanding of the potential applications of microcarriers but also opens up new horizons for advancing controlled drug release strategies, ultimately leading to more effective and personalized treatments for various diseases.

Keywords: Alginate; Controlled drug release; Curcumin; Microcarriers; Response surface method.