Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights

Front Immunol. 2025 May 15:16:1563553. doi: 10.3389/fimmu.2025.1563553. eCollection 2025.

Abstract

A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.

Keywords: IL-1; IL-36 pathway; acrodermatitis continua of Hallopeau; generalized pustular psoriasis; spesolimab.

Publication types

  • Case Reports

MeSH terms

  • Acrodermatitis* / complications
  • Acrodermatitis* / diagnosis
  • Acrodermatitis* / drug therapy
  • Antibodies, Monoclonal, Humanized* / therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Psoriasis* / complications
  • Psoriasis* / diagnosis
  • Psoriasis* / drug therapy
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal, Humanized