Association Between Autonomic Dysfunction and Empty Nose Syndrome

Cheng-Yu Li; Ta-Jen Lee; Yi-Wei Chen; Po-Hung Chang; Ya-Cheng Tang; Yu-Chieh Chen; Shu-Yen Wan; Chia-Hsiang Fu

doi:10.1002/alr.23618

Association Between Autonomic Dysfunction and Empty Nose Syndrome

Int Forum Allergy Rhinol. 2025 Sep;15(9):993-996. doi: 10.1002/alr.23618. Epub 2025 May 30.

Authors

Cheng-Yu Li¹, Ta-Jen Lee¹, Yi-Wei Chen¹, Po-Hung Chang^{1

2}, Ya-Cheng Tang¹, Yu-Chieh Chen³, Shu-Yen Wan³, Chia-Hsiang Fu^{1

2}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
² Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
³ Department of Information Management, Chang Gung University, Taoyuan, Taiwan.

PMID: 40444418
DOI: 10.1002/alr.23618

Abstract

Empty nose syndrome (ENS) is closely linked to autonomic dysfunction. Greater ENS symptom severity correlates with a higher autonomic symptom burden. Surgical treatment for ENS may alleviate autonomic dysfunction symptoms.

Keywords: autonomic system; composite autonomic symptom score 31 (COMPASS 31); empty nose; empty nose syndrome six‐item questionnaire (ENS6Q); postoperative outcome; sinonasal outcome test‐25 (SNOT‐25).

MeSH terms

Autonomic Nervous System / physiopathology
Autonomic Nervous System Diseases* / physiopathology
Autonomic Nervous System Diseases* / surgery
Humans
Nasal Obstruction* / surgery
Nose
Nose Diseases* / surgery
Prospective Studies
Syndrome

Grants and funding

CMRPG1P0041/Chang Gung Memorial Hospital