Rapid induction of extrapyramidal side effects with combined use of lithium and neuroleptics

J Clin Psychopharmacol. 1985 Oct;5(5):296-8. doi: 10.1097/00004714-198510000-00008.


Various forms of toxicity have been described when lithium and neuroleptics are used in combination. Two cases are presented in which extrapyramidal symptoms appeared soon after lithium was added to a regimen of neuroleptics. Clinical variables and pathophysiologic mechanisms are discussed. This reaction warrants further investigation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chlorpromazine / adverse effects*
  • Drug Interactions
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced / etiology*
  • Female
  • Haloperidol / adverse effects*
  • Humans
  • Lithium / adverse effects*
  • Male


  • Lithium
  • Haloperidol
  • Chlorpromazine