Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY ⁺CD8⁺ T cells

Affiliations

• ¹ Department of Gastrointestinal Surgery, Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
• ² Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
• ³ Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
• ⁴ Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
• ⁵ Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China lixiaox23@mail.sysu.edu.cn junyu@cuhk.edu.hk.
• ⁶ Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong lixiaox23@mail.sysu.edu.cn junyu@cuhk.edu.hk.