Objective: The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score has gained interest as a potential predictive biomarker for various clinical outcomes across multiple diseases. This study aimed to evaluate the efficacy of the HALP score in predicting the recurrence of atrial fibrillation (AF) following cryo-balloon ablation (CBA).
Method: A total of 399 patients who underwent CBA for AF were included in the study. Patients were divided into three equal groups based on their HALP scores, and post-procedural AF recurrence was evaluated retrospectively across these groups.
Results: After adjusting for confounding independent variables, patients in Tertile 1 had 2.1-fold higher rate of AF recurrence compared to those in Tertile 3, which served as the reference group. Receiver operating characteristic (ROC) curve analysis showed that the HALP score predicted AF recurrence with an area under the curve (AUC) of 0.69, 65% sensitivity, and 65% specificity (hazard ratio [HR]: 0.69, 95% confidence interval [CI]: 0.63-0.74, P < 0.001).
Conclusion: This study suggests that the HALP score may serve as an independent predictor of AF recurrence following CBA.