Impact of Adding Aromatherapy to Sound Intervention on Cardiovascular Parameters and Psychophysiological Measures in Cancer Patients: A Randomized Exploratory Trial

Oncol Res Treat. 2025;48(11):716-728. doi: 10.1159/000545932. Epub 2025 Jun 4.

Abstract

Introduction: Integrative therapeutic approaches are able to improve psychophysiological outcomes in cancer patients. Whether additional beneficial effects can be achieved by combining aromatherapy to sound intervention is unclear.

Methods: Eighty cancer patients were randomized (1:1) to either a 20-min sound intervention ("sound only," classical music via headphones) or a sound intervention combined with aromatherapy ("aroma"). Cardiovascular parameters (measured with VascAssist2.0), visual analogue scales for emotional well-being, anxiety, stress, pain and sadness, and the State Trait Anxiety Inventory were assessed before and after intervention.

Results: Sound only led to a significant reduction in the heart rate, while a trend for a lower heart rate was observed in the aroma group. Both pulse wave velocity (p = 0.04) and vascular resistance (p = 0.04) were reduced by sound only. Psychophysiological outcomes were improved by both interventions with a more pronounced but not significantly different effect on pain reduction by aroma (aroma p < 0.001; sound only p = 0.002).

Conclusion: Both interventions were able to improve psychophysiological outcomes. In terms of cardiovascular parameters, a sound intervention alone achieved greater but not significantly different results compared to aroma, while the addition of aromatherapy yielded no substantial additional effects.

Keywords: Anxiety; Aromatherapy; Cardiovascular parameters; Pain; Sound intervention.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anxiety / therapy
  • Aromatherapy* / methods
  • Combined Modality Therapy
  • Female
  • Heart Rate / physiology
  • Humans
  • Male
  • Middle Aged
  • Music Therapy* / methods
  • Neoplasms* / physiopathology
  • Neoplasms* / psychology
  • Neoplasms* / therapy
  • Treatment Outcome