Late onset epilepsy and dementia with Lewy bodies: Underestimated association?

Maximilien Porché; Julien Dumurgier; Claire Hourrègue; Claire Paquet

doi:10.1177/25424823251328613

Late onset epilepsy and dementia with Lewy bodies: Underestimated association?

J Alzheimers Dis Rep. 2025 Jun 2:9:25424823251328613. doi: 10.1177/25424823251328613. eCollection 2025 Jan-Dec.

Authors

Maximilien Porché^{1

2

3}, Julien Dumurgier^{2

3}, Claire Hourrègue², Claire Paquet^{2

3}

Affiliations

¹ Department of Neurology, Lariboisière Hospital, APHP, Paris, France.
² Center of Cognitive Neurology, Fernand-Widal Hospital, APHP, Paris, France.
³ Université Paris-Cité, GHU APHP Nord Lariboisière - Fernand Widal Hospital, Paris, France.

Abstract

Relationship between Alzheimer's disease (AD) and late onset epilepsy (LOE) has been widely described leading to an expansion of the clinical spectrum of AD. Dementia with Lewy bodies (DLB) has scarce data detailing its association with epilepsy. We report 4 patients presenting DLB and LOE. Most of them developed LOE before the first symptoms of DLB, they all presented Parkinsonism and cognitive fluctuations, half of them presented status epilepticus and none had co-amyloid pathology, sv2a inhibitors were poorly tolerated and routine EEG were often inefficient to diagnose epileptiform abnormalities.

Keywords: Alzheimer's disease; biomarkers; dementia with Lewy bodies; epilepsy.

Publication types

Case Reports