Predicting corticosteroid response in COPD using baseline bronchial biopsy DNA methylation

Tessa E Gillett; Corry-Anke Brandsma; Alen Faiz; Wim Timens; Gerard H Koppelman; Martijn C Nawijn; Maarten van den Berge

doi:10.1183/23120541.00724-2024

Predicting corticosteroid response in COPD using baseline bronchial biopsy DNA methylation

ERJ Open Res. 2025 Jun 2;11(3):00724-2024. doi: 10.1183/23120541.00724-2024. eCollection 2025 May.

Authors

Tessa E Gillett^{1

2}, Corry-Anke Brandsma^{1

2}, Alen Faiz^{2

3}, Wim Timens^{1

2}, Gerard H Koppelman^{2

4}, Martijn C Nawijn^{1

2}, Maarten van den Berge^{2

5}

Affiliations

¹ Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
² Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³ School of Life Sciences, Respiratory Bioinformatics and Molecular Biology, University of Technology Sydney, Sydney, Australia.
⁴ Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
⁵ Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Abstract

Blood eosinophil levels predict inhaled corticosteroid response to some extent in COPD but better biomarkers are needed. DNA methylation in bronchial biopsies shows potential to predict 30-month treatment response independent of blood eosinophils. https://bit.ly/4eKOC5t.

Publication types

Letter