Hospital variation in treatment for synchronous metastatic esophageal and gastric cancer: A nationwide population-based study in the Netherlands

Julie F M Geerts; Pauline A J Vissers; Bianca Mostert; Bas P L Wijnhoven; Brigitte C M Haberkorn; Marie-Paule G F Anten; Camiel Rosman; Geert-Jan Creemers; Harm Westdorp; Maurice J C van der Sangen; Rob H A Verhoeven; Grard A P Nieuwenhuijzen

doi:10.1002/ijc.35491

Hospital variation in treatment for synchronous metastatic esophageal and gastric cancer: A nationwide population-based study in the Netherlands

Int J Cancer. 2025 Jun 5. doi: 10.1002/ijc.35491. Online ahead of print.

Authors

Julie F M Geerts^{1

2

3}, Pauline A J Vissers^{3

4}, Bianca Mostert⁵, Bas P L Wijnhoven², Brigitte C M Haberkorn⁶, Marie-Paule G F Anten⁷, Camiel Rosman³, Geert-Jan Creemers⁸, Harm Westdorp⁹, Maurice J C van der Sangen¹⁰, Rob H A Verhoeven^{4

11

12}, Grard A P Nieuwenhuijzen¹

Affiliations

¹ Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.
² Department of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands.
³ Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁴ Department of Research & Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.
⁵ Department of Medical Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁶ Department of Medical Oncology, Maasstad Hospital, Rotterdam, The Netherlands.
⁷ Department of Gastroenterology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
⁸ Department of Medical Oncology, Catharina Hospital, Eindhoven, The Netherlands.
⁹ Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
¹⁰ Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands.
¹¹ Department of Medical Oncology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
¹² Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands.

PMID: 40470592
DOI: 10.1002/ijc.35491

Abstract

Care for metastatic esophageal (EC) or gastric cancer (GC) includes a large variety of treatment modalities. Data on treatment variation across centers are unknown. This study investigated treatment variation across hospitals and its effect on overall survival (OS) in the Netherlands by conducting a nationwide retrospective cohort study with population-based data from the Netherlands Cancer Registry. Patients diagnosed with synchronous metastatic EC/GC between 2015 and 2022 were included. Multilevel logistic regression assessed treatment patterns according to hospital of diagnosis. OS was analyzed using Cox regression analysis after categorizing hospitals into tertiles based on their adjusted odds (low/medium/high) for systemic treatment (chemotherapy, targeted therapy, and immunotherapy). Among 8406 EC and 3871 GC patients, the proportion receiving systemic treatment varied substantially: 19.8%-69.6% for EC and 15.8%-81.3% for GC across hospitals. Hospital of diagnosis was significantly associated with the adjusted probability of receiving systemic treatment (p < .0001). Ten out of 78 EC (12.8%) and 7 out of 73 (9.6%) GC hospitals had significantly lower systemic treatment probabilities. EC patients with OS ≥4 months diagnosed at hospitals with lower probabilities had significantly worse OS compared to high-probability hospitals (hazard ratios [HR] 0.87 [0.79-0.95] p = .002). GC patients from low-probability hospitals had significantly worse OS than from medium- (HR 0.86 [0.76-0.96], p = .011) or high-probability hospitals (HR 0.73 [0.64-0.82], p < .0001). In conclusion, this study showed substantial hospital variation in treatment for metastatic EC and GC. Hospital of diagnosis was not only associated with the probability of receiving systemic treatment but also OS. This reflects the challenge of ensuring equal healthcare access.

Keywords: esophageal cancer; gastric cancer; hospital variation; metastatic.