First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment

Peilin Liu; Xiaoda Cong; Jian Liang; Xiangkun Xu; Weili Zheng; Craig Stevens; Rohan Deraniyagala; Xiaoqiang Li; Xuanfeng Ding

doi:10.1016/j.ijpt.2025.100749

First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment

Int J Part Ther. 2025 Apr 20:16:100749. doi: 10.1016/j.ijpt.2025.100749. eCollection 2025 Jun.

Authors

Peilin Liu¹, Xiaoda Cong¹, Jian Liang¹, Xiangkun Xu¹, Weili Zheng¹, Craig Stevens¹, Rohan Deraniyagala¹, Xiaoqiang Li¹, Xuanfeng Ding¹

Affiliation

¹ Department of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.

Abstract

Purpose: Dynamic Spot-scanning Proton Arc (SPArc_-Dynamic) therapy has gained attention for enhancing dosimetric plan quality. However, its full clinical implementation remains under development. As an interim milestone, we developed step-and-shoot arc therapy (SPArc_-step&shoot) for head-neck cancer treatment.

Patients and methods: An in-house spot and energy-layer sparsity optimization algorithm was integrated into a clinical treatment planning system. The algorithm prioritized higher MU-weighted energy layers and spots to ensure delivery efficiency and superior plan quality while meeting machine requirements (≥0.02MU/spot). A Dynamic SPArc simulator calculated delivery times, and a machine-learning-based synthetic CT(synCT) platform monitored dose robustness. In June 2024, a head-neck cancer patient with parotid gland malignancy was treated using SPArc_-step&shoot (6600 cGy[relative biological effectiveness] in 33 fx) with 9 static fields at 20-degree intervals. Comparative plans (SFO-IMPT, SPArc_-Dynamic) were evaluated for dose metrics, delivery times, and adaptive planning.

Results: SPArc_-step&shoot and SPArc_-Dynamic showed similar target coverage and organ-at-risks sparing, and the plan quality is superior to the 3-field SFO-IMPT in the brainstem, oral cavity, and spinal cord sparing. The simulated continuous arc delivery time is 15.9, 6.32, and 4.31 minutes for SPArc_-step&shoot, SFO-IMPT, and SPArc_-Dynamic, respectively. The actual recorded average treatment delivery time for SPArc_-step&shoot in 33 fx is 16.7 ± 1.56 minutes. QA-CT and synCT showed a similar target coverage degradation and perturbation, and a replan was initiated.

Conclusion: The SPArc_-step&shoot therapy was successfully implemented in the clinical settings, and first patient was successfully treated between June and August 2024. The synCT platform serves a critical role in the daily monitoring process as SPArc_-Dynamic might be more sensitive to the patient geometry changes in HNC treatment.

Keywords: Adaptive planning; Neck-neck cancer; Step-and-shoot proton arc therapy.