Invasive bacterial infections (IBI) associated with drug use are increasing, but the full disease burden remains unknown. We characterized national trends in the prevalence of IBI among veterans with evidence of substance use using a large, national cohort. High rates of IBI highlight a need for more comprehensive infection reduction strategies, including emphasis on gram-negative infections.
Keywords: bacteremia; blood stream infections; substance use.
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.