CGRP increase in tear fluid of migraine patients is reversed by anti-CGRP monoclonal antibodies

J Neurol Neurosurg Psychiatry. 2025 Jun 6:jnnp-2025-335868. doi: 10.1136/jnnp-2025-335868. Online ahead of print.

Marina Romozzi^#^{1

2}, Lucia Di Nardo^#^{3

4}, Vincenzo Trigila⁵, Giovanni Cuffaro⁶, Gustavo Savino⁶, Luigi Francesco Iannone^{7

8}, Stanislao Rizzo⁶, Catello Vollono^#^{9

2}, Paolo Calabresi^#^{9

2}

¹ Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy marinaromozzi@gmail.com.
² Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
³ Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
⁴ Immunology Core Facility (GSTeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
⁵ Department of Ophthalmology, Università di Catania, Catania, Italy.
⁶ Ophthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
⁷ Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy.
⁸ Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
⁹ Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.

^# Contributed equally.

No abstract available

Keywords: HEADACHE; MIGRAINE.

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