Effects and interactions of natural cannabinoids on the isolated heart

Proc Soc Exp Biol Med. 1985 Nov;180(2):312-6. doi: 10.3181/00379727-180-42181.

Abstract

A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (delta P; an index of cardiac performance). In this preparation, delta 9- -tetrahydrocannabinol (THC) 2 X 10(-6) M to 10(-5) M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 X 10(-6) M). Tachycardia is associated with decreases in (delta P) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 X 10(-5) M. Cannabidiol (CBD) at concentrations of 9 X 10(-6) M to 10(-4) M has limited effect on rate while increasing delta P and coronary flow. Cannabinol (CBN) 8 X 10(-6) M to 3 X 10(-4) M depresses rate and delta P while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, delta P, and coronary flow.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Cannabidiol / pharmacology
  • Cannabidiol / toxicity
  • Cannabinoids / pharmacology*
  • Cannabinoids / toxicity
  • Cannabinol / pharmacology
  • Cannabinol / toxicity
  • Cardiac Output / drug effects
  • Coronary Circulation / drug effects
  • Dose-Response Relationship, Drug
  • Heart / drug effects*
  • Heart / physiopathology
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Tachycardia / chemically induced

Substances

  • Cannabinoids
  • Cannabidiol
  • Cannabinol