Advancing cancer precision surgery with the tumor coagulome

Abstract

Solid tumors generate a local and systemic procoagulant state, placing cancer patients at risk of hemostatic complications. The interplay between the tumor coagulome, a tumor-intrinsic determinant, and surgery-induced coagulopathy may influence the risk of recurrence following complete surgical resection. Perioperative targeting of the coagulome could advance cancer precision treatment.

Keywords: postsurgical recurrence; precision surgery; surgical resection; tumor coagulome.