Microscopic polyarteritis: presentation, pathology and prognosis

Q J Med. 1985 Aug;56(220):467-83.

Abstract

We have described 34 patients with microscopic polyarteritis, all of whom had clinical evidence of a systemic small vessel vasculitis predominantly affecting the skin and musculoskeletal systems accompanied by a focal necrotising glomerulonephritis with renal impairment. Thirty three patients received immunosuppressive treatment, comprising prednisolone, azathioprine, cyclophosphamide and plasma exchange in various combinations. The five-year actuarial patient and kidney survival rates were 65 and 55 per cent respectively, suggesting that aggressive immunosuppressive therapy in these patients is beneficial.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arteritis / diagnosis*
  • Arteritis / drug therapy
  • Arteritis / pathology
  • Azathioprine / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Female
  • Humans
  • Immunosuppression
  • Kidney / pathology
  • Lung / pathology
  • Male
  • Middle Aged
  • Muscles / pathology
  • Plasma Exchange
  • Prednisolone / therapeutic use
  • Prognosis
  • Skin / pathology

Substances

  • Cyclophosphamide
  • Prednisolone
  • Azathioprine