Non-coding RNAs in celiac disease

Asma Vafadar; Elham Shirazi-Tehrani; Parisa Vosough; Shayan Khalili Alashti; Hossein Kargar Jahromi; Kamran Bagheri Lankarani; Amir Savardashtaki; Sajad Ehtiati

doi:10.1016/j.cca.2025.120417

Non-coding RNAs in celiac disease

Clin Chim Acta. 2025 Aug 15:576:120417. doi: 10.1016/j.cca.2025.120417. Epub 2025 Jun 6.

Authors

Asma Vafadar¹, Elham Shirazi-Tehrani², Parisa Vosough¹, Shayan Khalili Alashti³, Hossein Kargar Jahromi⁴, Kamran Bagheri Lankarani⁵, Amir Savardashtaki⁶, Sajad Ehtiati⁷

Affiliations

¹ Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
² Department of Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC J2S 2M2, Canada.
³ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.
⁵ Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: Laknkaran@sums.ac.ir.
⁶ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: dashtaki63@gmail.com.
⁷ Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sajadehtiaty@gmail.com.

PMID: 40484302
DOI: 10.1016/j.cca.2025.120417

Abstract

Celiac disease (CeD) is a prevalent gluten-induced autoimmune condition that affects approximately 1%-2% of the global population. Recent research has emphasized the pivotal role of non-coding RNAs (ncRNAs) in regulating inflammatory responses and modulating autoimmune processes. This diverse group contains microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs),and serves as critical regulators in various physiological and disease-related pathways.A group of validated non-coding RNAs have emerged as promising biomarkers forthe diagnosis and treatment ofCeD.This review aims to elucidate the pathogenesis of CeD and investigate the potential of miRNAs, lncRNAs, and circRNAs as diagnostic biomarkers for this condition. By doing so, we hope to offer valuable insights into the underlying mechanisms of CeD and demonstrate the utility of ncRNAs as diagnostic and therapeutic tools in managing this autoimmune disorder.

Keywords: Celiac disease; Epigenetics; Non-coding RNA; circRNA; lncRNA; miRNA; ncRNA.

Publication types

Review

MeSH terms

Biomarkers
Celiac Disease* / diagnosis
Celiac Disease* / genetics
Humans
RNA, Circular
RNA, Untranslated* / genetics

Substances

RNA, Untranslated
Biomarkers
RNA, Circular