Retinal detachments are usually divided between rhegmatogenous and exudative. Many causes for exudative retinal detachments are described in the literature. Subretinal nematodes are a rare but well-known etiology for severe exudative retinal detachments and endophthalmitis. The case presented represents the first known infestation of human ocular tissue by the nematode Porrocaecum or Hexametra. Described are the presenting symptoms and medical and surgical management, including pars plana vitrectomy, retinotomy, and air-fluid exchange to salvage the eye.