Predicting who may benefit from adjuvant immunotherapy in stage IIB melanoma

Am J Surg. 2025 Sep:247:116450. doi: 10.1016/j.amjsurg.2025.116450. Epub 2025 May 29.

Abstract

Introduction: Adjuvant immunotherapy is approved for patients with Stage IIB melanoma but carries risks and costs. The aim of this study was to identify high-risk stage IIB patients to help inform adjuvant immunotherapy decisions.

Methods: The NCDB was queried to identify patients with stage IIB melanoma. Cox proportional hazards models identified risk factors for overall survival (OS). Conditional inference survival trees were used to create distinct risk groups. These groups were validated for melanoma-specific survival using SEER database.

Results: 12,610 patients were identified in the NCDB with Stage IIB melanoma. Three groups were identified with significant differences in OS: age <54, age ≥54 with MR ​≤ ​3/mm2, and age ≥54 with MR ​> ​3/mm2. Among the 7599 patients with Stage IIB melanoma in the SEER database, the cumulative incidence of melanoma-specific death at 5 years was significantly different between these groups (12 ​% vs 15 ​% vs 20 ​%).

Conclusions: Distinct melanoma-specific survival can be identified in stage IIB melanoma patients based on age and mitotic rate. These groups can be considered to inform decision-making for adjuvant therapy.

Keywords: Adjuvant; Immunotherapy; Melanoma; Survival.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Immunotherapy*
  • Male
  • Melanoma* / mortality
  • Melanoma* / pathology
  • Melanoma* / therapy
  • Middle Aged
  • Neoplasm Staging
  • Risk Assessment
  • Risk Factors
  • SEER Program
  • Skin Neoplasms* / mortality
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / therapy
  • Survival Rate