Burden of Headache Disorders in China and its Provinces, 1990-2021

Biomed Environ Sci. 2025 May 20;38(5):547-556. doi: 10.3967/bes2025.019.

Abstract

Objective: To analyze the prevalence and burden of headache disorders in China and its provinces from 1990 to 2021.

Methods: Using data from the Global Burden of Disease Study (GBD) 2021, the number of prevalent cases, prevalence rate, disability-adjusted life years (DALYs), and age-standardized DALY rates were analyzed by sex, age group, and province for headache disorders and their subtypes (migraine and tension-type headache [TTH]) between 1990 and 2021. Percentage changes during this period were also estimated.

Results: In 2021, approximately 426 million individuals in China were affected by headache disorders, with an age-standardized prevalence rate of 27,582.61/100,000. The age-standardized DALY rate for all headache disorders was 487.15/100,000. Between 1990 and 2021, the number of prevalent cases increased by 37.78%, while the prevalence of all headache disorders, migraine, and TTH increased by 6.92%, 7.57%, and 7.86%, respectively. The highest prevalence was observed in the 30-34 age group (39,520.60/100,000). Migraine accounted for a larger proportion of DALYs attributable to headache disorders, whereas TTH has a greater impact on its prevalence. In 2021, the highest age-standardized DALY rates for headache disorders were observed in Heilongjiang (617.85/100,000) and Shanghai (542.86/100,000).

Conclusion: The prevalence of headache disorders is increasing in China. Effective health education, improve diagnosis and treatment are essential, particularly for middle-aged working populations and women of childbearing age.

Keywords: Global burden of disease study; Headache disorders; Migraine; Tension-type headache.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • China / epidemiology
  • Cost of Illness*
  • Disability-Adjusted Life Years
  • Female
  • Headache Disorders* / epidemiology
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Prevalence
  • Young Adult