Mitogenic inhibition and effect on survival of mice bearing L1210 leukemia using a combination of dehydroascorbic acid and hydroxycobalamin

Am J Clin Oncol. 1985 Jun;8(3):266-9. doi: 10.1097/00000421-198506000-00013.

Abstract

The present study was designed to test the effect of a combination of dehydroascorbic acid (DHA) and hydroxycobalamin (vitamin B12) on the survival of mice bearing L1210 leukemia. Results showed a significant increase in survival of treated mice compared with controls (p less than or equal to 0.0001) (Student's t-test). This positive effect was significantly lost when DHA was substituted by ascorbic acid (AA) in the same experimental conditions. In vitro findings also revealed that the DHA-B12 combination specifically inhibited mitoses of L1210 cells while non-neoplastic L929 cells were not affected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cell Division / drug effects*
  • Cells, Cultured
  • Dehydroascorbic Acid / administration & dosage
  • Drug Evaluation, Preclinical
  • Female
  • Hydroxocobalamin / administration & dosage
  • Leukemia L1210 / drug therapy*
  • Leukemia L1210 / mortality
  • Mice
  • Mice, Inbred DBA

Substances

  • Hydroxocobalamin
  • Dehydroascorbic Acid