Left Ventricular Mesenchymal Hamartoma: Exploring Diagnostic Approaches and Potential Therapeutic Strategies

Chia-Jung Chen; Chung-Dann Kan

doi:10.1016/j.jaccas.2025.103636

Left Ventricular Mesenchymal Hamartoma: Exploring Diagnostic Approaches and Potential Therapeutic Strategies

JACC Case Rep. 2025 Jun 11;30(14):103636. doi: 10.1016/j.jaccas.2025.103636.

Authors

Chia-Jung Chen¹, Chung-Dann Kan²

Affiliations

¹ Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan.
² Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan. Electronic address: kcd5086@gmail.com.

Abstract

Cardiac hamartomas are rare benign tumors of disorganized native cardiac tissue that can cause obstruction, arrhythmias, or heart failure, despite their nonmetastatic nature. A 43-year-old woman with intermittent chest tightness and dyspnea underwent imaging suggestive of a malignant cardiac tumor. Intraoperative findings revealed a left ventricular basal inferoseptal hamartoma. Complete surgical resection was deemed too risky due to its location. Instead, transcatheter arterial embolization was performed to reduce the tumor's blood supply, and follow-up imaging showed regression. After ruling out malignancy, balancing the benefits of full surgical removal against the potential impact on cardiac function is crucial. In selected benign cases, transcatheter arterial embolization can be an effective, minimally invasive approach to control tumor growth and preserve heart function.

Keywords: cardiac tumor; mesenchymal hamartoma; transcatheter arterial embolization; ventricular mass.

Publication types

Case Reports