Burden of Disease and Spectrum of Illness From Enterovirus-D68 Infections in US Children 0-2 Years of Age From a Longitudinal Community-Based Cohort, 2017-2019

J Pediatric Infect Dis Soc. 2025 Aug 7;14(7):piaf057. doi: 10.1093/jpids/piaf057.

Abstract

In this 2017-2019 community-based cohort, 245 healthy children were followed from birth to age 2 years. A total of 46 enterovirus-D68 infections were detected by nasal swabs, all occurring between August and November 2018, with no detections in other study periods. About 46% of infections met acute respiratory illness criteria, of which 33% were medically attended; none required hospitalization.

Keywords: EV-D68; birth cohort; enteroviruses; epidemiology; viral infections.

MeSH terms

  • Child, Preschool
  • Cost of Illness*
  • Enterovirus D, Human* / isolation & purification
  • Enterovirus Infections* / epidemiology
  • Enterovirus Infections* / virology
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Infant, Newborn
  • Longitudinal Studies
  • Male
  • Respiratory Tract Infections* / epidemiology
  • Respiratory Tract Infections* / virology
  • United States / epidemiology