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, 48 (2), 289-97

Low-frequency Motions in Protein Molecules. Beta-sheet and Beta-Barrel

Low-frequency Motions in Protein Molecules. Beta-sheet and Beta-Barrel

K C Chou. Biophys J.


Low-frequency internal motions in protein molecules play a key role in biological functions. Based on previous work with alpha-helical structure, the quasi-continuum model is extended to the beta-structure, another fundamental element in protein molecules. In terms of the equations derived here, one can easily calculate the low-frequency wave number of a beta-sheet in an accordionlike motion, and the low-frequency wave number of a beta-barrel in a breathing motion. The calculated results for immunoglobulin G and concanavalin A agree well with the observations. These findings further verify that the observed low-frequency motion (or the so-called dominant low-frequency mode) in a protein molecule is essentially governed by the collective fluctuations of its weak bonds, especially hydrogen bonds, and the internal displacement of the massive atoms therein, as described by the quasi-continuum model.

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    1. Biopolymers. 1970;9(4):383-99 - PubMed
    1. Biophys Chem. 1984 Aug;20(1-2):61-71 - PubMed
    1. J Biol Chem. 1975 Feb 25;250(4):1525-47 - PubMed
    1. Science. 1975 Oct 31;190(4213):458-60 - PubMed
    1. Int J Pept Protein Res. 1975;7(4):333-4 - PubMed

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