Protective effects of extracellular proteins extracted from Saccharomycopsis fibuligera on UVA-induced skin aging

Abstract

Saccharomycopsis fibuligera plays a significant role in the fermentation industry. In this study, we extracted extracellular protein (SFEP) from S. fibuligera isolated in yellow rice wine wheat starter. We studied the effect of SFEP on UVA induced photoaging by examining several pathways: inflammation, abnormal matrix degradation, oxidative stress, mitochondrial function, and ferroptosis. Following UVA induction, SFEP demonstrated several protective effects: it reduced the secretion of inflammatory factors (IL-6, IL-8, and IL-1β), decreased matrix metalloproteinase expression, enhanced collagen, elastin, and fibronectin secretion, increased the activity of common antioxidant enzymes, limited lipid peroxide generation, and alleviated mitochondrial damage by preventing cell ferroptosis.

Keywords: Extracellular protein; Ferroptosis; Saccharomycopsis fibuligera; Skin photoaging; UVA.