Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein)

FEBS Lett. 1985 Oct 21;191(1):97-101. doi: 10.1016/0014-5793(85)81001-2.


A major 56 kDa substrate for phospholipid/Ca2+-dependent kinase (C-kinase) in pancreatic acinar cells is physicochemically and immunologically indistinguishable from the vitamin D-binding protein, Gc or group-specific component. Cellular Gc was also phosphorylated in intact cells following treatment with carbachol as a physiological stimulus. These findings indicate the potential usefulness of Gc as a defined substrate for further studies of the biological role of C-kinase activity in pancreatic acini and possibly in other cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / pharmacology
  • Pancreas / enzymology*
  • Phosphorylation
  • Protein Kinase C / analysis*
  • Rats
  • Vitamin D-Binding Protein / isolation & purification*


  • Vitamin D-Binding Protein
  • Protein Kinase C
  • Calcium