Unconjugated hyperbilirubinemia arises from elevated bilirubin production, impaired hepatic uptake, or reduced bilirubin conjugation, the latter often attributed to hereditary factors such as Gilbert syndrome involving mutations in the diphosphoglucuronate-glucuronosyltransferase 1A1 gene. Bilirubin levels in Gilbert syndrome typically range from 1.2 to 3.0 mg/dL, occasionally peaking up to 5.0 mg/dL. This case report details a jaundiced 24-year-old man with no significant medical history but otherwise asymptomatic presenting with indirect hyperbilirubinemia markedly elevated to 10.3 mg/dL.
Keywords: asymptomatic jaundice; hereditary hyperbilirubinemia; unconjugated hyperbilirubinemia.
© 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.